Marburg hemorrhagic fever in Uganda: Update on MSF's intervention

On 29 September, a Ugandan man, aged about thirty and presenting symptoms of hemorrhagic fever, died in a hospital in the Ugandan capital, Kampala. On 4th October, the Centre for Disease Control and Prevention (CDC) announced that the man's blood tests had revealed contamination by Marburg fever. Médecins Sans Frontières (MSF), which has been working in Uganda since 1986, is currently mobilising its teams in preparation for a response. 
Marburg hemorrhagic fever is an acute infectious viral disease belonging to the same family as Ebola. Unfortunately, it is often fatal. The modes of transmission (contact with certain animals – bats or monkeys - and between people  - direct contact with blood, body fluids, secretions and tissue from sick people, animals or dead bodies), and the symptoms (sudden onset of high fever, severe headaches, general pain and weakness, vomiting, diarrhoea, internal and external bleeding) are similar. During the incubation period (2 to 21 days), infected people are not contagious. 
"As with Ebola, there's no vaccine and no treatment other than supportive care (rehydration, stabilising blood pressure, reducing the fever, administering pain-killers and antiemetics)," explains Dr Estrella Lasry, MSF's adviser on tropical diseases. "The last Marburg epidemic in Uganda was in 2012. It lasted just over two months. There were 20 cases and 45% of them were fatal.  That same year there were also 2 Ebola epidemics in the country". 
MSF has been working in Uganda since 1986. "Usually, we run HIV and AIDS-related activities. But as on all our projects, our teams are always on stand-by to respond to emergency situations: in 2013/2014, it was assistance to Congolese and South-Sudanese refugees ; in 2012 it was a response to the Ebola epidemics", recounts Pierre Mendiharat, MSF’s programme manager in Uganda. 
The man who has just died lived near Mpigi, a district situated about 23 miles from Kampala. He was employed in one of the district's health centres and worked nights at Mengo hospital, in the heart of the capital. "The Ministry of Health and the CDC are currently trying to trace all the people who have been in contact with him and who may have been infected so they can - if necessary- be isolated and placed under surveillance" explained Pierre Mendiharat. "Mpigi and Mengo could be the first places that potentially infected people come to. The personnel needs to be properly protected (triage, "hazmat" suits, gloves and masks),so they can examine and refer suspected cases in complete safety." 
As with Ebola again, the family and health personnel in contact with infected patients are particularly at risk of contamination. In collaboration with the Ministry of Health, MSF is strengthening its capacity to respond to a potential epidemic. It is initially focusing its actions on health personnel supervision and training in clinical management of the disease and infection control measures. To do so, an emergency team is being put in place, made up of two coordinators, three medical staff (who have just finished their Ebola mission in West Africa) and two technicians specialised in water, hygiene and sanitation. A stock of specialised equipment was already on site and a full Ebola/Marburg treatment kit for 15 patients is on its way out to Kampala. MSF will supply "hazmat" suits and personal protective equipment (PPE) as well as specialised hygiene and sanitation equipment to the Mpigi and Mengo health centres. The centres' staff will be trained in the correct use of PPE and implementing infection control measures. In the referral centre at Kampala's Mulago hospital, where any suspected Marburg cases would be sent, MSF will rehabilitate the treatment unit and support the activities of the Ministry of Health should any patients be admitted. Lastly, an MSF ambulance will transport suspected cases from the health centres to Mulago hospital.